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Robson, Noorzurani and Mustafa, A. M. (2008) The effect of pretreatment with plant extract, nicotine and caffeine on sleeping time induced by pentobarbitone in mice. Internet Journal of Pharmacology, 5 (2). ISSN 1531-2976

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    Abstract

    Objective: To determine the effects of plant extract, nicotine and caffeine on the activities of the liver metabolizing-enzyme induced by pentobarbitone. Materials and Method: Seven groups of mice were pretreated with high doses of sample extracts (0.4 mg/g body weight sample extract, but nicotine at 0.1 mg/g body weight) and one control group was pretreated with saline. On day 5, pentobarbitone (0.005 ml of 8 mg/ml) was administered and the sleeping time was determined. The test was repeated but at low doses (0.1 mg/g body weight sample extract, but nicotine at 0.05mg/g body weight). Results: At high doses, bitter gourd, 'tempeh', nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the activities of liver metabolizing enzyme significantly compared to control. At low doses, bitter gourd, nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the enzyme but 'tempeh' did not. Conclusion: The findings suggest that bitter gourd, nicotine and caffeine act as enzyme inducers, but 'tempeh' only demonstrate this ability at high dose.

    Item Type: Article
    Uncontrolled Keywords: caffeine, cytochrome, enzyme, extracts, inducer, liver, metabolizing-enzyme, nicotine, p450, plant,
    Subjects: Medicine and Dentistry > Clinical Medicine
    Divisions: UNSPECIFIED
    Depositing User: Noorzurani Robson
    Date Deposited: 13 May 2012 13:04
    Last Modified: 13 May 2012 13:04
    URI: http://opendepot.org/id/eprint/1109

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