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Chen, Y. and Lim, B. K. and Hashim, O. H. (2009) Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma. Journal of Hematology & Oncology, 2. ISSN 1756-8722

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    Background: The general enhanced expression of alpha(1)-antichymotrypsin (ACT), clusterin (CLU), alpha(1)-antitrypsin (AAT), haptoglobin beta-chain (HAP), and leucine rich glycoprotein (LRG) in the sera of patients with epithelial ovarian carcinoma (EOCa) was recently reported. In the present study, we compared the expression of the serum acute-phase proteins (APPs) in the patients according to their stages of cancer. Results: Different altered stage correlative expression of the high abundance serum APPs was demonstrated in sera of the patients studied. While the expression of ACT, HAP and AAT appeared to demonstrate positive correlation with the three initial stages of the cancer, inverse correlation was apparently detected in the expression of LRG and CLU. For patients who were diagnosed with stage IV of the cancer, expression of the serum APPs did not conform to the altered progression changes. Conclusion: Our results highlight the potential prognostic significance of selective high abundance serum APPs in patients with EOCa.

    Item Type: Article
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    Uncontrolled Keywords: multidimensional liquid-chromatography gel-electrophoresis pancreatic-cancer lung-cancer plasma proteomics mass-spectrometry blood-serum cathepsin-d endometrial antigen
    Subjects: Medicine and Dentistry > Clinical Dentistry
    Divisions: UNSPECIFIED
    Depositing User: Mr Ahmad Azwan Azman
    Date Deposited: 15 Oct 2012 09:03
    Last Modified: 15 Oct 2012 09:03
    URI: http://opendepot.org/id/eprint/1430

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