A page from the OpenDepot.org service

Jump to the start of the main contents

Ping, K. Y. and Darah, I. and Yusuf, U. K. and Yeng, C. and Sasidharan, S. (2012) Genotoxicity of Euphorbia hirta: An Allium cepa Assay. Molecules, 17 (7). pp. 7782-7791. ISSN 1420-3049

[img]
Preview
PDF
Download (24Kb) | Preview
    [img] PDF
    Restricted to Registered users only

    Download (439Kb)

      Abstract

      The potential genotoxic effects of methanolic extracts of Euphorbia hirta which is commonly used in traditional medicine to treat a variety of diseased conditions including asthma, coughs, diarrhea and dysentery was investigated using Allium cepa assay. The extracts of 125, 250, 500 and 1,000 mu g/mL were tested on root meristems of A. cepa. Ethylmethanesulfonate was used as positive control and distilled water was used as negative control. The result showed that mitotic index decreased as the concentrations of E. hirta extract increased. A dose-dependent increase of chromosome aberrations was also observed. Abnormalities scored were stickiness, c-mitosis, bridges and vagrant chromosomes. Micronucleated cells were also observed at interphase. Result of this study confirmed that the methanol extracts of E. hirta exerted significant genotoxic and mitodepressive effects at 1,000 mu g/mL.

      Item Type: Article
      Additional Information: ISI Document Delivery No.: 978OI Times Cited: 0 Cited Reference Count: 19 Cited References: Akinboro A, 2007, J ETHNOPHARMACOL, V112, P470, DOI 10.1016/j.jep.2007.04.014 Carilta R, 2008, CHEMOSPHERE, V72, P722, DOI 10.1016/j.chemosphere.2008.03.056 Christopher H.B., 1988, CYTOLOGIA, V54, P203 FISKESJO G, 1985, HEREDITAS, V102, P99, DOI 10.1111/j.1601-5223.1985.tb00471.x GRANT WF, 1982, MUTAT RES, V99, P273, DOI 10.1016/0165-1110(82)90046-X KABARITY A, 1974, BIOL PLANTARUM, V16, P275, DOI 10.1007/BF02921238 KLASTERSKA I, 1976, HEREDITAS, V83, P153 LANHERS MC, 1991, PLANTA MED, V57, P225, DOI 10.1055/s-2006-960079 Leme DM, 2009, MUTAT RES-REV MUTAT, V682, P71, DOI 10.1016/j.mrrev.2009.06.002 MCGILL M, 1974, CHROMOSOMA, V47, P157, DOI 10.1007/BF00331803 MERCYKUTTY VC, 1980, CYTOLOGIA, V45, P769 Odeigah PGC, 1997, HEREDITAS, V126, P161, DOI 10.1111/j.1601-5223.1997.00161.x Ogbolie J.N., 2007, AFR J BIOTECHNOL, V6, P1544 Rank J, 1997, MUTAT RES-GEN TOX EN, V390, P121, DOI 10.1016/S0165-1218(97)00008-6 Sandeep B.P., 2009, J PHARM RES HLTH CAR, V1, P113 Sharma A.K., 1980, CHROMOSOME TECHNIQUE, P474 SHEHAB AS, 1983, CYTOLOGIA, V48, P343 Soetan KO, 2009, J MED PLANTS RES, V3, P324 Yi HL, 2003, MUTAT RES-GEN TOX EN, V537, P109, DOI 10.1016/S1383-5718(03)00054-8 Ping, Kwan Yuet Darah, Ibrahim Yusuf, Umi Kalsom Yeng, Chen Sasidharan, Sreenivasan Ministry of Higher Education of Malaysian Government Kwan Yuet Ping is supported by the MyPhD fellowship from Ministry of Higher Education of Malaysian Government. Mdpi ag Basel
      Uncontrolled Keywords: genotoxicity Allium cepa ethylmethane sulfonate mitotic index chromosome aberrations medicinal-plants chromosome stickiness root-tips aberrations mitosis water
      Subjects: Medicine and Dentistry > Clinical Dentistry
      Divisions: UNSPECIFIED
      Depositing User: Mr Ahmad Azwan Azman
      Date Deposited: 16 Oct 2012 02:06
      Last Modified: 16 Oct 2012 02:06
      URI: http://opendepot.org/id/eprint/1435

      Actions (login required)

      View Item