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Yeong, C. H. and Abdullah, B. J. J. and Ng, K. H. and Chung, L. Y. and Goh, K. L. and Sarji, S. A. and Perkins, A. C. (2011) Neutron-activated Sm-153-ion-exchange resin as a tracer for gastrointestinal scintigraphy. Nuclear Medicine Communications, 32 (12). pp. 1256-1260. ISSN 0143-3636

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    Abstract

    Nuclear medicine techniques are well established for the investigation of gastrointestinal (GI) motility and transit. Ion-exchange resins radiolabelled with Tc-99m and In-111 are widely used as nonabsorbable radiopharmaceutical markers, with In-111 being preferred for whole-gut transit studies. This radionuclide, however, is not produced in many countries and may be expensive when obtained through international shipment. This study describes the use of neutron-activated Sm-153-resin as an alternative tracer for use in GI scintigraphic investigation. A measure of 50 mg of stable samarium-152 chloride ((SmCl3)-Sm-152) was incorporated into 100 mg of cation-exchange resin and irradiated in a neutron flux of 1 x 10(13) cm(-2) s(-1) for 100 s to achieve an activity of 5 MBq after 66 h. Aliquots of In-111-radiolabelled resin (5 MBq) were prepared for comparison of labelling and stability. Radiolabelling efficiencies were obtained by washing resin with distilled water, and the activity lost was measured. The radiolabelled resins were immersed in simulated gastric and intestinal fluid environments, and the retention of Sm-153(3+) and In-111(3+) was measured over a 24 h period. At 66 h after production, 91.15 +/- 12.42 of Sm-153 was bound to the resin after washing in distilled water, whereas radiolabelling with In-111 achieved 99.96 +/- 0.02 efficiency. Both radiolabelled resins demonstrated almost 100 stability in simulated intestinal fluid and > 90 stability in artificial gastric juice over 24 h. The performance of neutron-activated Sm-153-resin is similar to that of In-111-resin and can be used as an alternative tracer for GI transit studies when In-111 is not available. Nucl Med Commun 32: 1256-1260 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. Nuclear Medicine Communications 2011, 32: 1256-1260

    Item Type: Article
    Additional Information: ISI Document Delivery No.: 851VL Times Cited: 1 Cited Reference Count: 21 Cited References: AWANG MB, 1993, J LABELLED COMPD RAD, V33, P941, DOI 10.1002/jlcr.2580331008 Bonapace ES, 2000, AM J GASTROENTEROL, V95, P2838, DOI 10.1111/j.1572-0241.2000.03195.x CAMILLERI M, 1989, AM J PHYSIOL, V257, pG284 Degen LP, 1996, GUT, V39, P299, DOI 10.1136/gut.39.2.299 DIGENIS GA, 1991, CRIT REV THER DRUG, V7, P309 FRIER M, 1994, EUR J NUCL MED, V21, P1234 Honkanen O, 2004, EUR J PHARM SCI, V21, P671, DOI 10.1016/j.ejps.2004.01.008 Kong MF, 1998, DIABETOLOGIA, V41, P577, DOI 10.1007/s001250050949 Lin HC, 2005, DIGEST DIS SCI, V50, P989, DOI 10.1007/s10620-005-2694-6 Marvola J, 2004, INT J PHARM, V281, P3, DOI 10.1016/j.ijpharm.2004.05.022 Marvola T, 2008, INT J PHARM, V349, P24, DOI 10.1016/j.ijpharm.2007.07.033 MATHER SJ, 1991, NUCL MED COMMUN, V12, P409 Mullan BP, 1998, NUCL MED COMMUN, V19, P237, DOI 10.1097/00006231-199803000-00007 Perkins AC, 2001, INT J PHARM, V222, P295, DOI 10.1016/S0378-5173(01)00722-0 Perkins AC, 1996, PHARM WORLD SCI, V18, P97, DOI 10.1007/BF00417757 PERKINS AC, 1995, EUR J NUCL MED, V22, P1035, DOI 10.1007/BF00808416 Thairs S, 1998, INT J PHARM, V176, P47, DOI 10.1016/S0378-5173(98)00305-6 TSE JW, 1989, J NUCL MED, V30, P202 WILDING IR, 1992, PHARMACEUT RES, V9, P1436, DOI 10.1023/A:1015858829187 Yeong CH, 2011, APPL RADIAT ISOTOPES, V69, P1181, DOI 10.1016/j.apradiso.2011.04.017 *ARSAC, 2006, NOT GUID CLIN ADM RA Yeong, Chai-Hong Abdullah, Basri Johan Jeet Ng, Kwan-Hoong Chung, Lip-Yong Goh, Khean-Lee Sarji, Sazilah Ahmad Perkins, Alan Christopher University of MalayaPS183/2009C; Ministry of Higher Education, MalaysiaFP067/2010B This study was supported by the University of Malaya Postgraduate Research Fund PS183/2009C and by the Fundamental Research Grant Scheme FP067/2010B from the Ministry of Higher Education, Malaysia. The neutron activation was supported by the Malaysian Nuclear Agency. The authors are grateful to Rehir Dahalan, Zulkifli Hashim and Julia Abdul Karim for their technical support in neutron activation. Lippincott williams & wilkins Philadelphia
    Uncontrolled Keywords: cation-exchange resin gamma scintigraphy In-111 radiolabelling radiopharmaceutical Sm-153 gamma-scintigraphy drug-delivery dosage forms transit formulations capsules men
    Subjects: Medicine and Dentistry
    Divisions: UNSPECIFIED
    Depositing User: Mr Ahmad Azwan Azman
    Date Deposited: 18 Oct 2012 02:15
    Last Modified: 18 Oct 2012 02:15
    URI: http://opendepot.org/id/eprint/1451

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