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Siar, C. H. and Mah, M. C. and Gill, P. P. (2012) Prevalence of bilateral 'mirror-image' lesions in patients with oral potentially malignant epithelial lesions. European Archives of Oto-Rhino-Laryngology, 269 (3). pp. 999-1004. ISSN 0937-4477

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      Early detection of oral potentially malignant epithelial lesions (PMELs) is aimed at improving survival rates as carcinogenesis is a multistep process and prevention is possible if these lesions are detected at an early and reversible stage of the disease. A prospective clinical study aimed at determining the prevalence of bilateral 'mirror-image' oral PMELs was carried out. Sample consisted of 32 (53.3) Indians, 23 (38.3) Chinese, 4 (6.7) Malays and one (1.7) Nepalese. All had histopathological confirmation of their primary existing PMEL as inclusion criteria. A total of 70 primary lesions were detected. The most common PMEL found was oral lichen planus. Of these, 28 (46.7) patients exhibited bilateral 'mirror-image' lesions (n = 42) either synchronously (n = 32/42) or metachronously (n = 10/42). The remaining 32 (53.3) patients had normal-looking contralateral mucosa. Present findings suggest that patients presenting with oral PMELs are at greater risk of developing a second lesion, most probably in the contralateral 'mirror-image' site.

      Item Type: Article
      Additional Information: ISI Document Delivery No.: 892ZU Times Cited: 0 Cited Reference Count: 27 Cited References: Barnes LEJ, 2005, WHO CLASSIFICATION T Hamadah O, 2009, BR J ORAL MAXILLOFAC, V48, P503 Koay CL, 2011, ORAL DIS, V17, P210, DOI 10.1111/j.1601-0825.2010.01724.x Lim GCC, 2008, 3 MIN HLTH MAL NAT C, P1 Lim JSM, 2009, ASIAN PAC J CANCER P, V10, P1071 Mattsson U, 2002, CRIT REV ORAL BIOL M, V13, P390 Mignogna MD, 2006, ORAL ONCOL, V42, P819, DOI 10.1016/j.oraloncology.2005.11.022 Mignogna MD, 2001, ORAL ONCOL, V37, P262, DOI 10.1016/S1368-8375(00)00096-8 Napier SS, 2008, J ORAL PATHOL MED, V37, P1, DOI 10.1111/j.1600-0714.2007.00579.x Ng K H, 1985, Southeast Asian J Trop Med Public Health, V16, P602 Ng KH, 1992, P SCI SEM IMR 90 ANN, P103 Ng K H, 1986, Ann Dent, V45, P7 Porter SR, 1998, BRIT DENT J, V185, P72, DOI 10.1038/sj.bdj.4809732 Rad M, 2009, ORAL SURG ORAL MED O, V107, P796, DOI 10.1016/j.tripleo.2009.02.020 Ram S, 2005, INT J ORAL MAX SURG, V34, P521, DOI 10.1016/j.ijom.2004.10.008 Reibel J, 2003, CRIT REV ORAL BIOL M, V14, P47 Scully C, 2008, BRIT J ORAL MAX SURG, V46, P15, DOI 10.1016/j.bjoms.2007.07.199 Scully C, 1998, CRIT REV ORAL BIOL M, V9, P86 SIAR CH, 1987, ORAL SURG ORAL MED O, V63, P216, DOI 10.1016/0030-4220(87)90315-X Siar CH, 1990, ASIAN MED J, V33, P697 Siar CH, 2009, EUR J MED RES, V14, P315 Silverman S, 2001, J AM DENT ASSOC, V132, p7S SLAUGHTER DP, 1953, CANCER, V6, P963, DOI 10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q Thomson PJ, 2002, INT J ORAL MAX SURG, V31, P262, DOI 10.1054/ijom.2002.0220 van der Meij EH, 2003, ORAL SURG ORAL MED O, V96, P164, DOI 10.1016/S1079-2104(03)00305-6 Yaacob Hashim B, 2002, J Oral Sci, V44, P65 Zain RB, 1997, COMMUNITY DENT ORAL, V25, P377, DOI 10.1111/j.1600-0528.1997.tb00959.x Siar, Chong Huat Mah, Michelle Clare Gill, Praveen Preet Department of Oral Pathology, Oral Medicine and Periodontology, Faculty of Dentistry, University MalayaDF OP411/0033/(U) The authors gratefully acknowledge all staff at the Department of Oral Pathology, Oral Medicine and Periodontology, Faculty of Dentistry, University Malaya, for their assistance in this project Ethics approval No. DF OP411/0033/(U). Springer New york
      Uncontrolled Keywords: Oral potentially malignant epithelial lesions Oral mucosa Clinical study Screening lichen-planus cancer surveillance carcinoma prognosis criteria malaysia
      Subjects: Medicine and Dentistry > Clinical Dentistry
      Divisions: UNSPECIFIED
      Depositing User: Ms Nursyafiqah Abd Malek
      Date Deposited: 30 Oct 2012 07:25
      Last Modified: 30 Oct 2012 07:25
      URI: http://opendepot.org/id/eprint/1501

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