A page from the OpenDepot.org service

Jump to the start of the main contents

Siar, C. H. and Oo, V. P. A. and Nagatsuka, H. and Nakano, K. and Ng, K. H. and Kawakami, T. (2009) Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions. European Journal of Medical Research, 14 (7). pp. 315-319. ISSN 0949-2321

Download (26Kb) | Preview


    Statement of the problem: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-invasive bronchial lesions, describes the presence of capillary tufts that are closely juxtaposed to and projecting into the dysplastic bronchial epithelium. Objective: To determine whether ASD-like phenomenon occurs in oral epithelial precursor lesions, and to speculate on its relevance. Methods: Twenty cases each of mild, moderate and severe oral dysplasia (inclusive of carcinoma-in-situ), and 10 normal oral mucosa (normal controls) were serial sectioned for H and E staining, and for microvessel density (MVD) scoring with CD31, CD34 and CD105. Microcapillary pattern images were digitally captured for 3-D reconstruction. Results: Oral ASD foci consisting of CD31- and CD34-positive capillary loops abutting onto the overlying dysplastic oral epithelium (and causing it to assume an irregular or papillary surface configuration) were identified in moderate (3/20; 15) and severe dysplasia (13/20; 65), but not in normal oral mucosa and mild dysplasia. MVD score demonstrated increasing vascularity as epithelium progressed from normal to severe dysplasia (p<0.05). CD105 demonstrated increase neo-vascularization in all dysplasia grades (p<0.05). Conclusions: These preliminary Findings taken together suggest that: 1. ASD-like phenomenon may be an important intermediary biomarker in oral precursor lesions; and 2. architectural alterations of the entire disturbed mucosa may be a more useful pre-malignancy index.

    Item Type: Article
    Additional Information: ISI Document Delivery No.: 495YR Times Cited: 5 Cited Reference Count: 14 Cited References: Barnes LEJ, 2005, WHO CLASSIFICATION T Bouquot J. E., 2006, CURR DIAGN PATHOL, V12, P11, DOI 10.1016/j.cdip.2005.10.008 Carlile J, 2001, J ORAL PATHOL MED, V30, P449, DOI 10.1034/j.1600-0714.2001.030008449.x FOLKMAN J, 1992, J BIOL CHEM, V267, P10931 Hirsch FR, 2002, EUR RESPIR J, V19, P1151, DOI 10.1183/09031936.02.00294102 Hirsch FR, 2001, CLIN CANCER RES, V7, P5 Keith RL, 2000, CLIN CANCER RES, V6, P1616 Kujan O, 2006, ORAL ONCOL, V42, P987, DOI 10.1016/j.oraloncology.2005.12.014 Lodi G, 2005, ORAL SURG ORAL MED O, V100, P164, DOI 10.1016/j.tripleo.2004.06.076 Macluskey M, 2000, J PATHOL, V191, P368, DOI 10.1002/1096-9896(2000)9999:9999<::AID-PATH652>3.3.CO;2-P Pazouki S, 1997, J PATHOL, V183, P39, DOI 10.1002/(SICI)1096-9896(199709)183:1<39::AID-PATH1088>3.3.CO;2-C Reibel J, 2003, CRIT REV ORAL BIOL M, V14, P47 Shibuya K, 2003, THORAX, V58, P989, DOI 10.1136/thorax.58.11.989 WEIDNER N, 1993, AM J PATHOL, V143, P401 Siar, C. H. Oo, V. P. A. Nagatsuka, H. Nakano, K. Ng, K. H. Kawakami, T. University of Malaya VoteF0209/2003A This study was funded by the University of Malaya Vote F0209/2003A. I holzapfel verlag gmbh Munich
    Uncontrolled Keywords: Oral precursor lesions angiogenic squamous dysplasia immunohistochemistry CD31, CD34 CD105 lung-cancer tumor progression malignant-transformation possible relevance high-risk tissues
    Subjects: Medicine and Dentistry > Clinical Dentistry
    Divisions: UNSPECIFIED
    Depositing User: Ms Nursyafiqah Abd Malek
    Date Deposited: 01 Nov 2012 02:15
    Last Modified: 01 Nov 2012 02:15
    URI: http://opendepot.org/id/eprint/1508

    Actions (login required)

    View Item