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Tsujigiwa, H. and Nagatsuka, H. and Han, P. P. and Gunduz, M. and Siar, C. H. and Oida, S. and Nagai, N. (2005) Analysis of amelogenin gene (AMGX, AMGY) expression in ameloblastoma. Oral Oncology, 41 (8). pp. 843-850. ISSN 1368-8375

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      Abstract

      Although the amelogenin gene is expressed in ametoblastoma, the precise expression pattern of X and Y amelogenin genes (AMGX, AMGY) in this tumor has not yet identified. In this study, we analyzed amelogenin gene expression in 19 samples (9 mate, 10 female) of oral amelobtastomas by RT-PCR and detect the chromosomal origin of amelogenin mRNA by restriction enzyme digestion of the RT-PCR product. All tumor samples expressed amelogenin mRNA. We could detect increased level of AMGY expression in all mate samples, higher than that of AMEX. It is an interesting finding as in normal mate tooth development, the expression of AMGY is very much lower than that of AMGX. We postulate that epigenetic change of sex chromosomes may have some correlations with tumorigenesis of ameloblastoma. We also discuss the other possible mechanisms and points for future studies on this change in expression pattern. (C) 2005 Elsevier Ltd. All rights reserved.

      Item Type: Article
      Additional Information: ISI Document Delivery No.: 964PZ Times Cited: 8 Cited Reference Count: 28 Cited References: AKIKO Y, 2001, MED ELECT MICROSC, V34, P185 Baba O, 2002, J HISTOCHEM CYTOCHEM, V50, P1229 Deutsch D, 1995, CONNECT TISSUE RES, V32, P97, DOI 10.3109/03008209509013710 Deutsch D, 1998, CONNECT TISSUE RES, V39, P177, DOI 10.3109/03008209809023924 Faerman M, 1995, GENE, V167, P327, DOI 10.1016/0378-1119(95)00697-4 Hirotsune S, 2003, NATURE, V423, P91, DOI 10.1038/nature01535 Iwase M, 2003, P NATL ACAD SCI USA, V100, P5258, DOI 10.1073/pnas.0635848100 KAORI S, 2001, ODONTOLOGY, V89, P28 KMAMOTO H, 2001, ORAL DIS, V7, P171 LAGERSTROMFERMER M, 1995, GENOMICS, V26, P159, DOI 10.1016/0888-7543(95)80097-6 LENCH NJ, 1994, HUM MOL GENET, V3, P827, DOI 10.1093/hmg/3.5.827 Li W, 1998, ARCH ORAL BIOL, V43, P497, DOI 10.1016/S0003-9969(98)00013-2 MORI M, 1991, VIRCHOWS ARCH A, V418, P319, DOI 10.1007/BF01600161 NAKAHORI Y, 1991, GENOMICS, V9, P264, DOI 10.1016/0888-7543(91)90251-9 Papagerakis P, 1999, J DENT RES, V78, P20 SAKU T, 1992, J ORAL PATHOL MED, V21, P113, DOI 10.1111/j.1600-0714.1992.tb00993.x SALIDO EC, 1992, AM J HUM GENET, V50, P303 SASAKI S, 1995, INT J DEV BIOL, V39, P127 Sasaki T, 1997, CIBA F SYMP, V205, P32 SCIUBBA JJ, 2001, BENIGN ODOTOGENIC TU, P71 SHAFER WG, 1983, CYSTS TUMORS ODONTOG, P276 SNEAD ML, 1988, DEVELOPMENT, V104, P77 SNEAD ML, 1992, ORAL SURG ORAL MED O, V74, P64, DOI 10.1016/0030-4220(92)90217-E TENCATE AR, 1985, DEV TOOTH ITS SUPPOR, P58 TERMINE JD, 1980, J BIOL CHEM, V255, P9760 Toyosawa S, 2000, GENE, V256, P1, DOI 10.1016/S0378-1119(00)00379-6 Veis A, 2003, CELL MOL LIFE SCI, V60, P38, DOI 10.1007/s000180300003 Veis A, 2000, J BIOL CHEM, V275, P41263, DOI 10.1074/jbc.M002308200 Tsujigiwa, H Nagatsuka, H Han, PP Gunduz, M Siar, CH Oida, S Nagai, N Elsevier science bv Amsterdam
      Uncontrolled Keywords: amelogenin AMGX AMGY ameloblastoma RT-PCR in situ hybridization odontogenic-tumors matrix proteins splice products enamel identification mutation cells end
      Subjects: Medicine and Dentistry > Clinical Dentistry
      Divisions: UNSPECIFIED
      Depositing User: Ms Nursyafiqah Abd Malek
      Date Deposited: 02 Nov 2012 02:18
      Last Modified: 02 Nov 2012 02:18
      URI: http://opendepot.org/id/eprint/1516

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