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Ngeow, W. C. and Chai, W. L. and Rahman, R. A. and Ramli, R. (2006) Managing complications of radiation therapy in head and neck cancer patients: Part I. Management of xerostomia. Singapore Dental Journal, 28 (1). pp. 1-3. ISSN 0377-5291

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    Head and neck cancer is becoming a more recognizable pathology to the general population and dentists. The modes of treatment include surgery and/or radiation therapy. Where possible, pretreatment dental assessment shall be provided for these patients before they receive radiation therapy. There are occasions, however, whereby head and neck cancer patients are not prepared optimally for radiation therapy. Because of this, they succumb to complicated oral adverse effects after radiation therapy. Part I of this series reviews the management of xerostomia. The management of the effect of xerostomia to the dentition/oral cavity is discussed in Part II.

    Item Type: Article
    Additional Information: Export Date: 5 April 2012 Source: Scopus PubMed ID: 17378333 Language of Original Document: English Correspondence Address: Ngeow, W.C.; Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia; email: ngeowy@um.edu.my Chemicals/CAS: pilocarpine, 148-72-1, 54-71-7, 92-13-7; Chewing Gum; Mouthwashes; Parasympatholytics; Pilocarpine, 92-13-7; Saliva, Artificial References: Shannon, I.L., Trodahl, J.N., Starcke, E.N., Radiosensitivity of the human parotid gland (1978) Proc Soc Exp Biol Med, 157, p. 50; Joyston-Bechal, S., Management of oral complications following radiotherapy (1992) Dent Update, 19, pp. 232-234,236-238; Epstein, J.B., Emerton, S., Lunn, R., Le, N., Wong, F.L.W., Pretreatment assessment and dental management of patients with nasopharyngeal carcinoma (1999) Oral Oncol, 35, pp. 33-39; Guchelaar, H.J., Vermes, A., Meerwaldt, J.H., Radiation-induced xerostomia. Pathophysiology, clinical course and supportive treatment (1997) Support Care Cancer, 5, pp. 281-288; Zain, R.B., Razak, I.A., Thong, Y.L., Complications in patients receiving radiation therapy in and around the oral cavity (1989) Dent J Malaysia, 11, pp. 44-48; Carl, W., Oral and dental care of patients receiving radiation therapy for tumours in and around the oral cavity (1986) Cancer and the Oral Cavity, pp. 167-183. , Carl W, Sako K, eds, Chicago: Quintessence; Frank, R.M., Herdly, J., Phillipe, E., Acquired dental defects and salivary gland lesions after irradiation for carcinoma (1965) J Am Dent Assoc, 70, pp. 868-883; Thomson, W.M., Chalmers, J.M., Spencer, A.J., Williams, S.M., The Xerostomia Inventory: A multi-item approach to measuring dry mouth (1998) Community Dent Health, 16, pp. 12-17; Thomson, W.M., Williams, S.M., Further testing of the xerostomia inventory (2000) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 89, pp. 46-50; Niedermeier, W., Matthaeus, C., Meyer, C., Staar, S., Muller, R.P., Schulze, H.J., Radiation-induced hyposalivation and its treatment with oral pilocarpine (1998) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 86, pp. 541-549; Mealey, B.L., Semba, S.E., Hallmon, W.W., The head and neck radiotherapy patient: Part 2 - Management of oral complications (1994) Compendium, 15, pp. 442-456; Davies, A.N., A comparison of artificial saliva and chewing gum in the management of xerostomia in patients with advanced cancer (2000) Palliat Med, 14, pp. 197-203; Toors, F.A., Chewing gum and dental health. Literature review (1992) Rev Belge Med Dent, 47, pp. 67-92; Nieuw Amerongen, A.V., Veerman, E.C., Current therapies for xerostomia and salivary gland hypofunction associated with cancer therapies (2003) Support Care Cancer, 11, pp. 226-231; Duxbury, A.J., Thakker, N.S., Wastell, D.G., A double-blind cross-over trial of a mucin-containing artificial saliva (1989) Br Dent J, 166, pp. 115-120; McClure D, Barker G, Barker B, Feil P. Oral management of the cancer patient: Part II. Oral complications of radiation therapy. Compendium 1987;8(2):88,90-2Hay, K.D., Gear, K.J., Xerostomia and you (2002) N Z Dent J, 98, pp. 46-51; Scholz-Ahrens, K.E., Schrezenmeir, J., Effects of bioactive substances in milk on mineral and trace element metabolism with special reference to casein phosphopeptides (2000) Br J Nutr, 84 (SUPPL. 1), pp. S147-S153; Reynolds, E.C., Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: A review (1998) Spec Care Dentist, 18, pp. 8-16; Hay, K.D., Thomson, W.M., A clinical trial of the anticaries efficacy of casein derivatives complexed with calcium phosphate in patients with salivary gland dysfunction (2002) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 93, pp. 271-275; Wiseman, L.R., Faulds, D., Oral pilocarpine: A review of its pharmacological properties and clinical potential in xerostomia (1995) Drugs, 49, pp. 143-155; Hawthorne, M., Sullivan, K., Pilocarpine for radiation-induced xerostomia in head and neck cancer (2000) Int J Palliat Nurs, 6, pp. 228-232; Frydrych, A.M., Davies, G.R., Slack-Smith, L.M., Heywood, J., An investigation into the use of pilocarpine as a sialagogue in patients with radiation induced xerostomia (2002) Aust Dent J, 47, pp. 249-253; Oral pilocarpine: new preparation. Xerostomia after radiation therapy: moderately effective but costly. Prescrire Int 2002;11:99-101Deutsch, M., The use of pilocarpine hydrochloride to prevent xerostomia in a child treated with high dose radiotherapy for nasopharynx carcinoma (1998) Oral Oncol, 34, pp. 381-382; Davies, A.N., Singer, J., A comparison of artificial saliva and pilocarpine in radiation-induced xerostomia (1994) J Laryngol Otol, 108, pp. 663-665; Johnstone, P.A., Peng, Y.P., May, B.C., Inouye, W.S., Niemtzow, R.C., Acupuncture for pilocarpine-resistant xerostomia following radiotherapy for head and neck malignancies (2001) Int J Radiat Oncol Biol Phys, 50, pp. 353-357
    Uncontrolled Keywords: Complication Head and neck cancer Management Xerostomia cholinergic receptor blocking agent pilocarpine saliva substitute chemistry chewing gum drug effect head and neck tumor human mouth hygiene radiation injury review salivation Head and Neck Neoplasms Humans Mouthwashes Parasympatholytics Radiation Injuries Saliva, Artificial
    Subjects: Medicine and Dentistry
    Divisions: UNSPECIFIED
    Depositing User: Associate Professor Dr. Wen Lin Chai
    Date Deposited: 24 Apr 2012 08:29
    Last Modified: 24 Apr 2012 08:29
    URI: http://opendepot.org/id/eprint/989

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